In our study, the overexpression of AEG-1/MTDH in ovarian carcinomas indicates an important role for AEG-1/MTDH in epithelial ovarian carcinogenesis and is consistent with the findings of a small number ofstudies of AEG-1/MTDH in ovarian cancer so far; AEG-1/MTDH was found to have a prognostic significance as a biomarker of distal metastasis [22], whereas high expression of AEG-1/MTDH was significantly associated with poorer overall survival and disease-free survival in another study in ovarian cancer patients [23]. This evidence concerns the gene MTDH and ovarian carcinoma.