In consistence with our findings, Song et al. demonstrated a gradual increase in the expression level of AEG-1/MTDH when moving from low grade benign colonic tumours (cytoplasmic expression primarily) through to frank colorectal adenocarcinoma (nuclear expression), whereas AEG-1/MTDH expression was again associated with shorter survival [17]. Here, MTDH is linked to colorectal adenocarcinoma.