It has been shown that progenitor or stem cells which are enriched with CD133+ and OCT-4 have higher colony-forming capacity [5], in addition, the expression of OCT-4 in dedifferentiated cells leads to cancer stem-like cell features with the acquired ability to form tumor spheroids, increased resistance to chemotherapeutic agents, and increased tumorigenic capacity [28]. The gene discussed is POU5F1; the disease is neoplasm.