However, recent studies from several laboratories have linked more closely malignant transformation (oncogenesis), tumor angiogenesis, and metastasis to the generation of clotting intermediates (e.g., tissue factor (TF), factor Xa, and thrombin), clotting or platelet function inhibitors (e.g., COX-2), or fibrinolysis inhibitors (e.g., plasminogen activator inhibitor, type 1 (PAI-10)) [4]. The gene discussed is F3; the disease is neoplasm.