While the mechanistic basis for the association between high RBM3 expression and good prognosis needs to be further elucidated, some directions may be provided by the observed association between RBM3 expression and DNA integrity and repair [12], and the ability of RBM3 to attenuate stem-cell like properties of prostate cancer cells [13]. The gene discussed is RBM3; the disease is Familial prostate cancer.