Some studies have demonstrated an association between RBM3 expression and proliferation in vitro as well as in various normal proliferating and malignant tissues [21], however in our previous study on malignant melanoma, there was no significant association between expression of RBM3 and Ki67, but a significant inverse correlation between RBM3 expression and another proliferation marker, the minichromosome maintenance 3 (MCM3) protein [23]. This evidence concerns the gene MCM3 and melanoma.