CATSPER2 and deafness-infertility syndrome: CNVs have also been identified as a cause of non-syndromic hearing loss (NSHL), the most well-known example being deletion of a segmental duplication region of chromosome 15 that includes the gene STRC and causes autosomal recessive NSHL (ARNSHL) at the DFNB16 locus[5,6] or deafness-infertility syndrome (DIS) if the adjacent CATSPER2 gene also is involved[7].