Because the cell-cycle analysis and investigation of caspase-3 and caspase-7 activation indicated no significant overall difference between the effects of AE-CA and CPT, the enhanced cytotoxicity of AE-CA might also be the result of unidentified components of the AE-CA that exert additive antitumor effects in human endometrial carcinoma cells. The gene discussed is CASP7; the disease is endometrial carcinoma.