IL1B and systemic-onset juvenile idiopathic arthritis: Anakinra, an anti-IL-1 whose effectiveness was tested for rheumatoid arthritis, Still's disease, and Muckle-Wells syndrome, seems to be a valid alternative in some cases of GCA, resistant or refractory to the steroid methotrexate or with azathioprine treatments, or even with etanercept, even if its use in GCA is limited to case reports [62].