GWAS for CD shows the genes regulating autophagy, including autophagy 16-like 1 (ATG16L1), immunity-related guanosine triphosphatase M (IRGM), and leucine-rich repeat kinase 2 (LRRK2) genes, which are associated with CD risk [8, 9]. The gene discussed is IRGM; the disease is Cowden disease.