Similarly, MultiBLUP regions can overlap, which we illustrate for CD by constructing regions based on two pathways (IL-2 receptor beta chain in T cell activation and IL12 pathway) and two genes (NOD2 and IL23R), all of which have shown association with the trait in at least two data sets other than the WTCCC1 (Agura et al. 2001; Hugot et al. 2001; Duerr et al. 2006; Wang et al. 2009; Ballard et al. 2010). Here, NOD2 is linked to Cowden disease.