MAPK8 and metabolic dysfunction-associated steatohepatitis: Given previous reports on the crucial function of JNK in the mediation of NASH fibrosis (Schattenberg et al, 2006), we further examined the functional role of JNK in RIP3-dependent NASH fibrosis and treated groups of Casp-8LPC-KO mice with repetitive injections of the well-established JNK-inhibitor SP600125 or vehicle substance as control in parallel to MCD-diet feeding.