CYP2E1 and metabolic dysfunction-associated steatohepatitis: To examine the functional role of RIP3 in NASH development, we applied the methionine- and choline-deficient (MCD) diet-induced model of steatohepatitis that mimics important features of human NASH, including the development of steatohepatitis, CYP2E1 overexpression, and increased lipid peroxidation as well as the promotion of NASH toward hepatic fibrosis (Schattenberg et al, 2006).