CASP8 and metabolic dysfunction-associated steatohepatitis: Moreover, in contrast to previous assumptions (Hatting et al, 2013), our findings indicate that the main function of Caspase-8 in the MCD-NASH model is to counterbalance the deleterious hyperactivation of RIP3-dependent necroptosis, underlining the mutual inhibitory functions of RIP3 and Caspase-8 that were previously demonstrated, for example in embryonic development (Kaiser et al, 2011) and skin homeostasis (Weinlich et al, 2013).