CASP8 and metabolic dysfunction-associated steatohepatitis: In order to examine the differential functions of RIP3-dependent necroptosis versus Caspase-8-dependent apoptosis in NASH, we generated mice with conditional deletion of Caspase-8 in liver parenchymal cells (LPC)—hepatocytes and cholangiocytes—(Casp-8LPC-KO), constitutive ablation of Rip3 in all cells (RIP3−/−), and mice with combined conditional and constitutive deletions of Caspase-8 and RIP3, respectively (Casp-8LPC-KO/RIP3−/−) (Supplementary Fig S1).