Given previous reports on the essential functional role of the MCP-1/CCR2 axis in monocyte recruitment and liver fibrosis (Seki et al, 2009; Baeck et al, 2012), these data indicate that MCP-1 represents one important factor linking RIP3-dependent necroptosis in NASH with liver fibrosis. Here, CCL2 is linked to Hepatic fibrosis.