CASP8 and Hepatic fibrosis: We have recently shown that Caspase-8-dependent apoptosis but not RIP3-dependent necroptosis promoted liver fibrosis and hepatocarcinogenesis in a model of liver injury caused by conditional deletion of the kinase TGF-β-activated Kinase-1 (Tak1) in parenchymal liver cells (Vucur et al, 2013).