TNF and metabolic dysfunction-associated steatohepatitis: Further analyses revealed increased TNF levels in WT and Casp-8LPC-KO mice after 8 weeks of MCD feeding, as well as a strong correlation between RIP3 expression levels and levels of TGF-β2 (Supplementary Fig S7), which is in line with a recent report showing a prominent role of TGF-β in the regulation of NASH-associated hepatocyte cell death (Yang et al, 2014).