APOE and triple-A syndrome: AAA lesion inflammation (macrophage-positive area, T-cell content, dendritic cell content, major histocompatibility complex [MHC] class-II content, and chemokine monocyte chemoattractant protein-1 [MCP-1] content), lesion cell proliferation (Ki67-positive areas), microvessel number (CD31), apoptotic cell number, media elastin fragmentation, and presence of SMC in the tunica media (loss of media SMCs) were all significantly lower in AAA lesions from Apoe−/−Fcer1a−/− mice than in lesions from Apoe−/− mice (Fig 2D and E).