IGHE and triple-A syndrome: To test this hypothesis, we administered an anti-IgE mAb intravenously 1 day before initiating the AAA (Ang-II mini-pump implantation), and once more at 2 weeks after AAA initiation using doses previously established as effective in allergic mice and humans (Coyle et al, 1996; Haile et al, 1999; Milgrom et al, 1999; Leung et al, 2003; Busse et al, 2011).