IGHE and chronic rhinosinusitis: Mast cells inactivation by blocking IgE activity by use of anti-IgE antibodies has been investigated widely among patients with allergic asthma, food allergy, atopic dermatitis, atopic eczema, chronic autoimmune urticaria, and chronic rhinosinusitis (Milgrom et al, 1999; Leung et al, 2003; Busse et al, 2011).