Reconstitution of macrophages from Apoe−/− mice, but not those from Apoe−/−Fcer1a−/− mice, also increased lesion macrophage-positive area, T-cell number, and MHC class-II-positive area (Fig 5C), establishing a role of IgE actions on macrophages in AAA lesions. The gene discussed is APOE; the disease is triple-A syndrome.