Increased plasma IgE in AAA mice (Fig 2A and C), reduced AAAs in FcεR1-deficient Apoe−/−Fcer1a−/− mice (Fig 2B), and increased IL6 and IFN-γ and reduced IL10 in CD4+ T cells after IgE activation (Fig 1E and F) suggest a role of IgE actions on CD4+ T cells in AAAs. Here, APOE is linked to achalasia-alacrima syndrome.