Ggly also stimulates CRC cell proliferation via both MAPK/ERK‐ and PI3K‐dependent pathways (Ferrand et al. 2006), and inhibits CRC cell apoptosis by activation of PI3K, Janus kinase 2 (JAK2), and JNK pathways (Beales and Ogunwobi 2006). This evidence concerns the gene JAK2 and colorectal carcinoma.