Even though gastrins stimulate cell proliferation and migration (Huynh et al. 2013), and β‐catenin signaling and VEGF production (Fig. 3), in CRC cells, the upregulation of gastrins via removal of the inhibitory feedback loop demonstrated in this study does not compensate for the reduction in these functions as a result of PAK1 knockdown. This evidence concerns the gene PAK1 and colorectal carcinoma.