p21‐activated kinase 1 enhances proliferation, migration/invasion, and survival of CRC cells by activation of ERK and AKT, as knockdown of PAK1 by small interfering RNA (siRNA) dramatically reduced cell proliferation, migration/invasion, and survival, as well as the activities of ERK and AKT (Huynh et al. 2010). Here, AKT1 is linked to colorectal carcinoma.