INS and metabolic dysfunction-associated steatohepatitis: High dose insulin (100 mU/m2/min) suppressed glycerol release in both patients with NASH and in controls, however, the rate of glycerol release remained significantly higher in the NASH subjects compared with controls (261 ± 31 vs. 65.8 ± 14 μmol/l·h; p < 0.0001; Figure 3B).