During the two-step hyperinsulinaemic clamp, NASH subjects had significantly lower weight-adjusted glucose infusion rates in response to low-dose (1.47 ± 0.08 vs. 3.08 ± 0.4 mg/kg/min; p = 0.0008) and high-dose insulin (5.80 ± 0.4 vs. 9.14 ± 0.5 mg/kg/min; p < 0.0001). This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.