INS and metabolic dysfunction-associated steatohepatitis: In keeping with peripheral (largely muscle) IR, weight-adjusted Gd rates were significantly lower in NASH subjects at low-dose (0.85 ± 0.1 vs. 1.76 ± 0.4 mg/kg/min; p < 0.05) and high-dose insulin infusions (4.55 ± 0.6 vs. 6.10 ± 0.5 mg/kg/min; p = 0.05) (Figure 1C).