TP53 and B-cell chronic lymphocytic leukemia: In considering the cytotoxic activity of DCA+Nutlin-3 in p53wild-type B-CLL cells, it is noteworthy that rapamycin, like DCA, decreases the Warburg effect by inhibiting the mTOR pathway [27] and that also Nutlin-3 via p53 can inhibit the mTOR pathway [28,29].