In addition, a group of transcription factors have been demonstrated to be capable of orchestrating EMT programmes in cancer progression, including direct transcriptional repressors of E-cadherin, like Snail (SNAI1), Slug (SNAI2), ZEB2 (SIP1) and others transcription factors like Twist, ZEB1 and FOXC2, whose role in metastasis depends on the microenvironment, cell type and other signalling within the cells [34]. The gene discussed is TWIST1; the disease is cancer.