The contribution of Vav1 in tumorigenic properties of solid tumors has only been assigned so far to its GEF activity [8, 10, 11] and, in breast tumor-derived cell lines, a dual potential role of Vav1 as an oncogenic stress activator as well as an apoptotic inducer dependent from p53 availability was reported [14]. Here, VAV1 is linked to breast neoplasm.