LOX and neoplasm: Indeed, these bioactive compounds explicate anticarcinogenic effects by inhibition of cyclooxygenase-2 (COX-2) and lysyl oxidase (LOX) and inhibition of an activation factor, Nuclear Factor-Kappa B (NF-Κβ), thereby decreasing invasion, angiogenesis and metastasis; moreover, these components promote a significant decrease of total hepatic cytochrome P450 content which activates procarcinogens and inhibits tumor initiation; furthermore, pomegranate-derived bioactive compounds inhibit enzymes like carbonic anhydrase and ornithine decarboxylase that are active in cancer cells growth [14].