Furthermore, analyses of immune-precipitates from tumor lysates by an antibody against p38γ, Hsp90 or K-Ras revealed that there is a ternary-complex formation, which is disrupted by the 17-AAG treatment in both tumors, leading to a down-regulation of K-Ras expression (Figure 3E/F). Here, HSP90AA1 is linked to neoplasm.