Furthermore, in agreement with reports in esophageal SCC, treatment with 5-Aza, a specific inhibitor of DNA methylation, led to a significant increase in MT3 expression in AML cells (39.8 fold in HL-60 and 26.8 fold in MV4-11; P < 0.05 and P < 0.01, respectively). The gene discussed is MT3; the disease is esophageal squamous cell carcinoma.