MT3 and leukemia: Our results showed that the MT3 promoter was hypermethylated in 7/11 leukemia cell lines, with the highest methylation levels observed in HL-60, MV4-11 SHI-1, U937 and K562 cells; whereas it was unmethylated in 4/11 cell lines, 697, SHI-1, THP-1 and Jurkat (Figure 2B).