Pathway analysis of ING1-repressed genes showed that breast cancer had the strongest association (p=0.0008; kappa similarity score=1.0 where 0.75-1.0=very high; 0.5-0.75=high, 0.25-0.5=moderate and below 0.25=low) followed by colorectal cancer (supplementary Fig1B, 1C), while genes transcriptionally activated had less clear links to cancer pathways (data not shown). The gene discussed is ING1; the disease is colorectal cancer.