When combined together, AG14361 and lestaurtinib exhibited a much stronger inhibitory effect on the expression of a number of genes in the NF-κB signaling pathway, such as p50, p65, IL6, IL8, COX2 and MMP9 that are involved in cancer cell proliferation, inflammation, invasion and/or cell death [45,50,54,58,59]. This evidence concerns the gene MMP9 and cancer.