We tested levels of proliferation by MTT (Figure 1C), clonogenic assays (Figure 1D), and tumor growth (Figure 1E) of these isogenic cell lines, and found that the 92 J pair (92 J-shBRCA1 and 92 J- wtBRCA1) and MDA-MB-231 pair (MDA-MB-231-shBRCA1 and MDA-MB-231-wtBRCA1) exhibited similar growth, irrespective of their BRCA1 status (Figure 1E). The gene discussed is BRCA1; the disease is neoplasm.