Multivariable analysis revealed that AST (>50 IU/L), liver cirrhosis, perioperative transfusion, multiple tumors, microvascular invasion, and Edmondson-Steiner grade III to IV were independent adverse prognostic factors for disease-free survival; while serum albumin (≤3.5 g/dL), low platelet count (≤100,000 mm3), perioperative transfusion, perioperative morbidity, tumor size larger than 3 cm, multiple tumors, macrovascular invasion, and Edmondson-Steiner grade III to IV were independent adverse prognostic factors for overall survival (Table 2). The gene discussed is ALB; the disease is cirrhosis of liver.