In this study, we investigated 18 prognostic factors, including patients factors (which are age, gender, serum albumin, ALT, AST, platelet count, and liver cirrhosis), surgical factors (which are perioperative transfusion, perioperative bleeding, perioperative morbidity, surgical resection margin, and extent of resection), and tumor factors (which are tumor size, number of tumors, macroscopic vascular invasion, microscopic vascular invasion, histologic grades, and serum AFP level). This evidence concerns the gene AFP and cirrhosis of liver.