Male sex, serum albumin lower than 3.5 g/dL, liver cirrhosis, perioperative transfusion, intraoperative bleeding greater than 1,000 cc, perioperative complications, multiple tumors, and Edmondson-Steiner grade III to IV were independent adverse prognostic factors for overall survival of patients with tumors larger than 3 cm in multivariate analysis. This evidence concerns the gene ALB and cirrhosis of liver.