TNBC with family history may influence the BRCA mutation; when the 96 TNBCs were broken down into different age groups, BRCA1 and BRCA2 mutations were 25% (5/20) in unselected women (≤ 35 years old) with TNBC and 33.3% (2/6) were in women (≤35 years old) with FH and/or BI-BC TNBC, respectively. The gene discussed is CACNA1A; the disease is breast cancer.