CD40LG and myeloid sarcoma: The intriguing observation that certain monoclonal antibodies IgM immunoglobulin induce remyelination in the toxin-mediated (lysolecithin [224,225]), autoimmune (EAE, [226]) and virus-induced Theiler’s murine encephalomyelitis (TMEV) [227] models of inflammatory demyelination resembling MS has been examined, and several mouse [228] and human [229] monoclonal antibodies identified.