HMOX1 and posterior cortical atrophy: This was observed for both, HO-1 transiently and stably transfected cells (1.5 and 2.0 fold respectively, P<0.05; Fig. 1D), which demonstrates that HO-1 is capable of modulating the adhesive response of PCa cells and it is consistent with our previous published work where cells displaying high levels of HO-1 appear to acquire a less malignant phenotype, with decreased cellular proliferation, migration and invasion [20].