There were no differences between the active and sedentary groups in the number of APOE-ε4 allele carriers, and the analysis of risk for AD was adjusted for age at follow-up, sex, education, follow-up time, locomotor dysfunction, midlife body mass index, systolic blood pressure, cholesterol, history of myocardial infarction, stroke, and diabetes mellitus. The gene discussed is APOE; the disease is diabetes mellitus.