The deregulation status of most of these 31 genes appeared to be greatly context-dependent, as evaluated by using entropy-based feature selection across 14 HD-associated conditions including murine striatum and human (postmortem brains, blood samples, induced pluripotent stem cells) datasets (Table S7) [5], which emphasizes the importance of context (e.g., cell type, time requirement) in future analyses of the physiological impact of abnormal Ryk signaling on FOXO activity in HD. The gene discussed is RYK; the disease is Huntington disease.