Additionally, FOXO factors may be important to the regulation of neuron survival in neurodegenerative diseases such as Huntington's disease (HD) [4],[5], a dominantly inherited CAG repeat disorder caused by expanded polyglutamines (polyQ) in the N-terminal portion of huntingtin (HTT) and characterized by striatal and cortical degeneration [6]. This evidence concerns the gene HTT and neurodegenerative disease.