With the exception of indicators of muscle weakness (ataxia, sarcopenia and kyphosis) and of spontaneous tumours, all tested biomarkers of ageing were more frequently positive in 36-week-old nfkb1−/− mice as in their wt counterparts and often reached levels similar to wt mice aged ≥2 years (Table 2). Here, NFKB1 is linked to cerebellar ataxia.