Our findings suggest that there is a significant association between rs1042714 polymorphism of ADRB2 and obesity: OR = 0.86 for the allelic genetic model, OR = 1.2 for the dominant genetic model, OR = 0.99 for the recessive genetic model, OR = 1.01 for the homozygote genetic model, OR = 1.16 for the heterozygote genetic model. Here, ADRB2 is linked to obesity due to melanocortin 4 receptor deficiency.