In 2008, Jalba and colleagues [43] performed a meta-analysis involving ADRB2 gene and obesity and conducted statistical analysis in three ways: the heterozygote comparison (Gln/Glu vs. Gln/Gln), the homozygote comparison (Glu/Glu vs. Gln/Gln) and the dominant model (Gln/Glu + Glu/Glu vs. Gln/Gln). The gene discussed is ADRB2; the disease is obesity due to melanocortin 4 receptor deficiency.