Interestingly, GluN3A expression is induced by OGD (Figure 9B), corroborating the results obtained in a recent study showing that GluN3A protein levels increase in neurons submitted to OGD and focal ischemia [43], but in disagreement with an earlier report showing that focal ischemia down-regulates GluN3A at the mRNA and protein levels 24 h after the insult [67]. The gene discussed is GRIN3A; the disease is ischemia.