Taken in combination with published data from the California Childhood Leukemia study [19], and the results of LDsplit analyses which indicate multiple cis-acting sequences, including loci identified in the SNP association studies, contributing to recombination at DNA3, this is suggestive of an association of these haplotypes and recombination events affecting HLA-DOA, with BCP-ALL. Here, HLA-DOA is linked to acute lymphoblastic leukemia.