Based on the multivariate linear regression analysis, the duration of the uremia, systolic blood pressure, LVST, E/E' ratio, and the levels of the total cholesterol, glyceride, Hb, CRE, and BUN were associated with the 3DS, LS, RS and CS, which were used to examine the risk factors for preclinical myocardial systolic dysfunction. The gene discussed is GSTM1; the disease is uremia.