In the cross-sectional analyses, statistically significant associations of the SNP rs4402960 located in gene IGF2BP2 with overweight and the SNP rs1801131 in gene MTHFR with hypertension were observed in our model 1 adjusting for age, sex, life style factors (leisure time physical activity, alcohol consumption, smoking status, and educational level). The gene discussed is IGF2BP2; the disease is hypertensive disorder.