Biological functional evidence depicted the INSIG2 gene from the very start as a candidate gene for obesity as being involved in the reversed cholesterol transport by an interaction with sterol regulatory element-binding proteins (SREBPs) [43], which are transcription factors that activate the synthesis of cholesterol and fatty acids in the liver and other organs [44]. The gene discussed is CNBP; the disease is obesity due to melanocortin 4 receptor deficiency.