[18], [20], [21] Small deletions very close to the translocated genes have been reported in 10-30% of patients with CBF-AML [t(8;21) and inv(16)] and CML [t(9;22)], usually involving the translocated genes.[10], [14] Less frequently (∼1%), some cases have been described in such leukemias with deletions located in more telomeric or centromeric regions from the translocated gene, [10], [14] resembling our case APL_20. Here, CEBPZ is linked to acute myeloid leukemia.