This region has shown susceptibility to rearrangement and explains the relative high frequency of i(17q) in hematologic and non-hematologic cancers, as well as deletions in this area in Smith-Magenis syndrome.[15], [16] The fact that the i(17q) harbours the t(15;17) indicates that the i(17q) occurs as a secondary event, that in addition will produce an extra RARA-PML transcript.[17]. Here, RARA is linked to Smith-Magenis syndrome.