Recently two muscle-specific atrophy-related ubiquitin ligases, Atrophy gene-1/Muscle Atrophy F-box (Atrogin-1/MAFbx) and Muscle Ring-Finger protein 1 (MuRF1), which are transcriptionally upregulated during early stages of muscle atrophy have been found [22]. The gene discussed is FBXO32; the disease is Atrophy.