Highly selective dipeptidyl peptidase IV (DPP IV) inhibitors are quite different from conventional antidiabetic agents and control hyperglycemia by stimulating insulin production via the prevention of the degradation of two major incretins, the glucagon-like peptide-1 (GLP-1) and the glucose inhibitory peptide (GIP) [5]–[7]. The gene discussed is DPP4; the disease is Hyperglycemia.