Conversely, we found that the expression of IRF9 (P = 7.9e−6), IL12RB2 (P = 4.9e−3), SHC4 (P = 5.6e−3), IL12B (P = 9.5e−3), IL13 (P = 1.3e−2), ITPR2 (P = 1.4e−2), PTPN11 (P = 1.7e−2), STAT5 (P = 2.3e−2) and IL4 (P = 3.7e−2) genes were predominantly regulated by cis-acting elements in CD4+ T cells from RA patients. The gene discussed is ITPR2; the disease is rheumatoid arthritis.