It was found in this study that the SIRT1 expression and activity were decreased in CCI mice (Fig. 1 and 3) and modulations of SIRT1 activity by NAD (Fig. 4) or resveratrol (Fig. 5) ameliorated the development of neuropathic pain, suggesting that SIRT1 and its substrates [42] may be involved in the reprogramming process of the development of neuropathic pain. This evidence concerns the gene SIRT1 and Pain.