DMD and Duchenne muscular dystrophy: Starting from data from DMD clinical trials that confirmed how the therapy with prednisone ameliorated the pathological phenotype and strength of muscle [81], they suggested that immunosuppression not only ameliorated the efficiency of transduction mediated by the AAVs but above all limited the degeneration of myofibers blocking the immunological cells that recognize and destroy newly formed dystrophin positive myofibers [80].