NOTCH1 and acute lymphoblastic leukemia: The potent role of Notch signaling in T-cell leukemogenesis and >50% presence of activating Notch1 gene mutation in T-ALL has prompted the testing of GSIs in multiple clinical trials, though most results are unpublished, BMS-906024 (NCT01363817), RO4929097 (NCT01088763), MK0752 [NCT00100152 (60)], PF03084014 (NCT00878189), and LY3039478 (NCT01158404).