In typically MYC-driven Burkitt lymphoma, 7% (5/70) carry Notch1 mutations (40), 8% (5/63) of BCL2-associated diffuse large B-cell lymphoma (DLBCL) carry similar PEST mutations of Notch2, and 6% (2/35) had amplification of the Notch2 locus (41). Here, NOTCH1 is linked to diffuse large B-cell lymphoma.