Experimental evidence demonstrates that Notch inhibition by either mAb against Notch1 or Notch2 appears to have anti-tumor and anti-angiogenic effects with limited gastrointestinal toxicities while simultaneous inhibition of Notch1 and 2 lead to gastrointestinal toxicity, as seen with many GSIs (77–79). Here, NOTCH1 is linked to neoplasm.