NOTCH2 and neoplasm: However, a recent study found that inactivation of Notch signaling in murine bone marrow led to a myeloproliferative disease, and identified inactivating mutations in Notch pathway genes (NCSTN, APH1, MAML1, and NOTCH2) in 12% (5/42) CMML patient samples, implicating a tumor suppressor role for Notch in this disease (48).