IFNG and coinfection: These stressors include, nutrient and iron deprivation (Raulston, 1997; Igietseme et al., 1998), specific antibiotics (Matsumoto and Manire, 1970; Clark et al., 1982), co-infection with herpes simplex virus (HSV) (Vanover et al., 2008), exposure of infected cells to the danger signal adenosine (Pettengill et al., 2009), and interferon gamma (IFNγ) (Beatty et al., 1993), the latter of which, under optimal conditions, is believed to be a key immune mediator in resolution of, and subsequent protection from, infection(Rank and Whittum-Hudson, 2010; Aiyar et al., 2014).