TNC and neoplasm: Interestingly, Sorrentino et al. demonstrated that miR-355, which has been shown to inhibit tumor metastasis by targeting TNC expression (31, 33, 36) was down-regulated in three OC cell lines resistant to paclitaxel and one cell line resistant to cisplatin, suggesting potential connection between ECM alteration and EMT transformation that can lead to chemo-resistance in OC (24).