As an HSA molecule binds up to seven molecules of LCFA according to the physical condition of the body, e.g. ordinarily the LCFA content of HSA is 1–2, but during a fast or after hard exercise, or in subjects suffering from diabetes, it binds LCFA at the highest level of 6–7, the results of the present study suggest that the concentration of unbound TFZ in the blood, which relates closely to its pharmacological activity, may be influenced by the condition of the body through the LCFA content in HSA. This evidence concerns the gene ALB and diabetes mellitus.