KBTBD13 and nemaline myopathy: KBTBD13 forms a complex with Cul3 ubiquitin ligase through its N-terminal BTB domain and this interaction is required for the formation of a functional Cul3 ubiquitin ligase complex, suggesting that the pathogenic mechanism in KBTBD13-related nemaline myopathy may involve dysregulation of cellular protein ubiquitination[66].