NFKB1 and myeloproliferative disorder: As compared to other iron chelators, DSX is a potent NF-kB inhibitor and is able to increase glutathione (GSH) in red blood cells, thus protecting them from oxidative insults.25 Despite these observations, the role of ICT in PMF remains largely undefined, and a few reports are present in the literature regarding this specific setting of Philadelphia-negative chronic myeloproliferative neoplasm (MPN Ph-),26–29 reflecting the limited expertise in this field.