Chromosomal translocations affecting the IG loci are recurrent in CHL and involve partners as BCL6, MYC, BCL3, RELB, REL and BCL2. 44,45 At least one among the PIM1, PAX5, RhoH/TTF, and c-MYC genes is involved by an aberrant somatic hypermutation process in 55% of classical HL cases, 2 or more being mutated in 30% of patients.16 Such rates are indeed lower than the ones recorded in NLPHL. This evidence concerns the gene MYC and classic Hodgkin lymphoma.