Lymphoid anergy is well-known in the biology and pathogenesis of cHL and T-cell homing is central in determining the immunological regulation of HRS growth and survival.13,14 The lymphoid infiltrate in HL is different from the aspecific one detectable in reactive lymphoid hyperplasia (RLH), since the CD3+/CD20+ ratio is greater in HL than in RLH,15 with augmented CD4+CD25+ infiltrate.15,16. This evidence concerns the gene CD4 and Hodgkins lymphoma.