A common immune escape strategy of HRS cells is to down-regulate the expression of human leukocyte antigen (HLA) -A,-B and -C (classic: MHC Ia) and to modify the expression of HLA-G and E (no classical: MHC Ib), as seen in about 20% and 80% of primary cases of EBV+ and EBV- cHL, respectively. The gene discussed is HLA-G; the disease is classic Hodgkin lymphoma.