Main factors involved in lymphocyte migration into the tumor milieu include CCL20,21 CCL5/Rantes, IL-7, CCL17 and CCL22.22 CXCR3, CXCR4, CXCL13 and CCR7, and adhesion molecules including CD62 ligand (CD62L), are greatly expressed on T-cells of cHL patients.23 HRS cells are also able to express chemokine receptors useful to T-cell migration into tumor milieu, such as CXCL12 (receptor of CXCR4) and CXCR5 (receptor of CXCL13).24 Here, CXCR4 is linked to classic Hodgkin lymphoma.