KLRD1 and Hodgkins lymphoma: More specifically, LBH589 induces cell death, autophagy, and an increase of major histocompatibility complex (MHC) class I chain-related genes molecules (MICA/B); that act as key ligands for NK cell receptors, and also favourably modulates the cytokine network and lymphocyte activity in the HL microenvironment.12 Studies of innovative therapies based on the immune system of HL patients treated with chemo/radiotherapy and targeting NK cells rather than T cells are, therefore, extremely promising.