Genomic aberrations of FLT3, including internal tandem duplication (ITD) and point mutations, have been demonstrated in approximately 25–35% of adults with acute myeloid leukemia (AML).3–7 ITD of the FLT3 gene is common in AML and is associated with a bad prognosis and poor response to chemotherapy. Here, FLT3 is linked to acute myeloid leukemia.