As a hypoxia-dependent protein, HIF-1α can be rapidly degraded when oxygen is normal, but when oxygen is not sufficient, it can upregulate cell proliferation at the transcription level, activate the expression of numerous hypoxia response genes, and be closely associated with energy metabolism, angiogenesis, infiltration and metastasis of the tumor by binding with the hypoxia response element of the hypoxia response (12). Here, HIF1A is linked to neoplasm.