A 56-year-old male who had been diagnosed with Her2-positive advanced GC with multiple lymph node metastases, including left supraclavicular, paraaortic and retroperitoneal lymph nodes, underwent 12 cycles of combination chemotherapy composed of trastuzumab (Her2 monoclonal antibody), capecitabine and cisplatin at the Konkuk University Medical Center (Seoul, Korea). This evidence concerns the gene ERBB2 and metastatic malignant neoplasm in the lymph nodes.