With the progress of high-throughput genomics and proteomics technology, increasing prostate cancer-related tumor markers, such as MIB-1/Ki67 labeling indices, DD3, EGR-1 and Bcl-2, are constantly being discovered and used in the diagnosis and prediction of prognosis of prostate cancer (30,31). The gene discussed is MKI67; the disease is Familial prostate cancer.